CALL FOR PAPERS Mitochondrial Metabolism Quantitative characterization of changes in the cardiac mitochondrial proteome during anesthetic preconditioning and ischemia
نویسندگان
چکیده
Martin Bienengraeber, Molly Pellitteri-Hahn, Naoyuki Hirata, Tesfaye M. Baye, Zeljko J. Bosnjak, and Michael Olivier Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin; Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin; and Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin
منابع مشابه
Quantitative characterization of changes in the cardiac mitochondrial proteome during anesthetic preconditioning and ischemia.
Changes in mitochondrial bioenergetics have been proposed to be critical for triggering and effecting anesthetic-induced preconditioning (APC) against cardiac ischemia and reperfusion injury. The objective of this study was to analyze changes in mitochondrial protein levels and link those changes to potential functional changes. A (18)O-labeling method was applied for relative comparison of car...
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NADH increases during ischemia because O(2) shortage limits NADH oxidation at the electron transport chain. Ischemic (IPC) and anesthetic preconditioning (APC) attenuate cardiac reperfusion injury. We examined whether IPC and APC similarly alter NADH, i.e., mitochondrial metabolism. NADH fluorescence was measured at the left ventricular wall of 40 Langendorff-prepared guinea pig hearts. IPC was...
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